The effect of high intensity ultrasound on micro-vessels in a tumor in a rabbit liver
- VernacularTitle:高强度超声对兔肝肿瘤微血管损伤作用的病理观察
- Author:
Li-Ming GUAN
;
Zhi-Biao WANG
;
Feng WU
;
Jin BAI
;
Shuang WEN
;
Chong-Yan LI
;
Yong-Hong DU
;
- Publication Type:Journal Article
- Keywords:
High intensity ultrasound;
Tumors;
Micro-vessels
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the damage caused by high intensity ultrasound(HIU)on tumor micro- vessels.Methods Rabbit models of the VX_2 tumor were set up.The target hepatic carcinomas were treated with HIU,and the results were observed using hematoxylin-eosin(HE)staining,vascular endothelial cell biotinylated-ulex europaeus agglutininiⅠ(UEAI)immunohistochemical staining,tumor micro-vessel counts,and electron microscopy. Results Histological examination through HE staining indicated that HIU induced carcinoma vascularities with whole tumor tissue coagulative necrosis.The UEAI immunohistochemical staining of the target lesions treated by HIU was ne- gative,and complete tumor micro-vessel uhrastructure damage was observed under the electron microscope.Conclu- sion HIU can damage tumor micro-vessels thoroughly,in such way that it may inhibit tumor growth and metastasis.
