Effects of electric stimulation on Nogo-A expression in hippocampus of rats
- VernacularTitle:电刺激对海马表达Nogo-A蛋白的影响
- Author:
Nan-Xiang XIONG
;
Hong-Yang ZHAO
;
Fang-Cheng ZHANG
;
- Publication Type:Journal Article
- Keywords:
Hippocampus;
Nogo-A;
Electrical stimulation;
Epilepsy
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of chronic electrical stimulation (ES) on Nogo-A expression in the hippoeampus of rats.Methods Thirty male Wistar rats were randomly divided into a control group and 4 exper- imental groups.The rats in the control group were given sham ES,while those in the experimental groups received 1, 3,6,or 9 days of ES before being sacrificed for the detection of Nogo-A expresson in the hippoeampus by immunohis- tochemistry and Western plotting.Results There was a positive correlation between the level of Nogo-A expression and the duration of ES,as shown by the immunohistochemistry technique.Western blotting showed the same result. Conclusion In general,seizure occurred 8 days after electrical stimulation began.Elevated Nogo-A expression in the hippocampus began earlier than seizures in the epilepsy model groups.
