Changes of VEGF protein and mRNA in the vulva of rabbits after ultrasound irradiation
- VernacularTitle:超声作用兔外阴皮肤后组织中VEGF蛋白和mRNA的变化
- Author:
Jian-Wu ZHAO
;
Zhi-Biao WANG
;
Zheng-Ai XIONG
;
Cheng-Zhi LI
;
- Publication Type:Journal Article
- Keywords:
Ultrasound irradiation;
Vulva skin;
VEGF;
White vulval lesions
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate ultrasound as a therapy for white lesions of the vulva.Methods Immunohistochemistry and hybridization in situ were used to study changes in VEGF protein and mRNA in the vulva skin of rabbits after ultrasound irradiation.Results After irradiation,VEGF protein and mRNA had increased markedly after 4 and 7 days,but their levels recovered by day 14.Conclusion Ultrasound irradiation causes local edema and hypoxia which enhance production of VEGF.VEGF promotes growth of local microvessels and increases the permeability of the endothelial cells of blood vessels.These changes improve nutrition of the mierovessels and nerve endings and ameliorate the microenvironment for tissue growth.One could speculate that ultrasound irradiation helps rehabilitation and regeneration of pathologic vulva skin.
