The expression of CDld in systemic lupus erythematosus patients with antiphospholipid syndrome
- VernacularTitle:系统性红斑狼疮合并抗磷脂综合征患者外周血CD1d的表达
- Author:
Chun-Ming LI
;
Yuan WANG
;
Xiao-Xiang CHEN
;
Li-Ping GUO
;
- Publication Type:Journal Article
- Keywords:
Antigen CD1;
Lupus erythematosus,systemic;
Antiphospholipid syndrome;
Flow cytometry
- From:
Chinese Journal of Rheumatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of CDId with APS and laboratory data,by examin- ing the CDld expression of PBMC from systemic lupus erythematosus(SLE)patients with antiphospholipid syndrome.Methods The CDld expression of 20 SLE patients with APS,30 SLE controls and 23 normal con- trois were detected by flow cytometry.The relationship between CDld expression and clinical,laboratory data of patients with SLE was analysed.Results The expression of CDld in PBMC of SLE patients with APS was higher than normal controls,but had no difference with SLE controls.The expression of CDld in monocyte group of SLE patients with APS was higher than normal controls,which had no difference with SLE controls. Highly significant correlations was found between CDld expression and SLEDAI while,negative correlation between CDld expression and complements was discovered.Conclusion The abnormal expression of CDld may play a role in the pathogenesis of SLE,it may be a parameter for assessing disease activity.
