Association of nonalcoholic fatty liver disease with tumor necrosis factor-? gene polymorphisms
- VernacularTitle:肿瘤坏死因子-?基因多态性与非酒精性脂肪性肝病的关系
- Author:
Yong ZHOU
;
Li JIAN
;
YU-YUAN
;
Yuqiang NIE
;
- Publication Type:Journal Article
- Keywords:
Nonalcoholic fatty liver disease;
Tumor necrosis factor;
Gene polymorphisms
- From:
Chinese Journal of Digestion
1996;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevalence of tumor necrosis factor-?(TNF-?)promoter polymorphisms(at position-308 or-238)in patients with nonalcoholic fatty liver disease(NAFLD),and to explore the relationship between TNF-? promoter polymorphisms and obesity and the insulin resis tance(IR)in those patients.Methods Metabolic variables were measured in 117 patients with NAFLD, among them 60 were obesity and 57 were non-obesity.Genotype of TNF-? promoter were determined by PCR-RFLP.Plasma TNF-? level was measured by ELISA.Indexes of IR and insulin secretion were determined using the homeostasis model assessment method.One hundred and twenty normal subjects who were matched for age and sex served as control.Results The G→A mutation of the-238 TNF-? polymorphism was significantly higher in patients with NAFLD versus controls(29.9% vs.15.8%, P
