Pharmacokinetics of Paclitaxel Lyophilized Injection in rat
- VernacularTitle:紫杉醇冻干注射剂在大鼠体内的药代动力学
- Author:
Xuenong ZHANG
;
Lihua TANG
;
Xueying YAN
;
Qiang ZHANG
;
- Publication Type:Journal Article
- Keywords:
paclitaxel;
pharmacokinetic;
pattern paramete;
HPLC
- From:
Chinese Traditional Patent Medicine
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the pharmacokinetics of Paclitaxel Lyophilized Injection and Taxol in rats. METHODS: Paclitaxel inclusion lyophilized Injection was prepared with hydroxylpropyl ? inclusion as the inclusion vehicle. At the same time, Paclitaxel Lyophilized Injection pharmacokinetic pattern and parametes had been modeled with 3p87 program and statistic rules comparing with Taxol. RESULTS: Paclitaxel Lyophilized Inject and Taxol abided by two department model. The parametes T 1/2? (3.40?0.27)h and AUC (34.46?4.34) mg?L -1 ?h,MRT 3.50 h to Lyophilized Injection and T 1/2? (3.50?0.62)h, AUC (25.73?6.42) mg?L -1 ?h,MRT 2.52 h to Taxol. CONCLUSION: The results indicate that distribution rate of the two preparations are in coincidence with in rats and Paclitaxle Lyophilized extends the retention time of paclitaxel in rats.
