Effects of Xifeng Zhijing Capsule on Experimental Parkinson's Disease in Mice
- VernacularTitle:熄风止痉胶囊对小鼠实验性帕金森病的防治作用
- Author:
Li XU
;
Cui'E WE
;
Jianxun LIU
;
Darong CHEN
;
- Publication Type:Journal Article
- Keywords:
Xifeng Zhijing Capsule;
Parkinson's disease;
Tremor;
Oxygenated tremorine;
Dopamine
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Xifeng Zhijing Capsul e on experimental Parkinson's disease(PD) in mice. Methods Mouse model of Parkin son's disease was established by intraperitoneal injection of 1- methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP) and mouse model of tremor was estab lished by intraperitoneal injection of oxygenated tremorine. Effects of Xifeng Z hijing Capsule on cerebral concentration of monoamine neurotransmitters such as dopamine (DA), 3, 4- dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and its influence on the latency, duration and amplitude of tremor in th e extremities were observed. Results Xifeng Zhijing Capsule significantly incr eased the cerebral concentrations of DA, DOPAC and HVA in mice, and decreased the amplitude and duration of tremor in mice extremities. Conclusion Xifeng Z hijing Capsule has preventive and therapeutic effect for PD.
