Comparative Studies on the Anti- inflammatory and Analgesic Actions of Huang qi Guizhi Wuwu Decoction and Its Compositions
- VernacularTitle:黄芪桂枝五物汤及其配伍抗炎镇痛的比较研究
- Author:
Zhaosheng HUANG
;
Xuguang SHI
;
Wei ZHU
;
Zhendong ZHAO
;
Zhongwei WANG
;
- Publication Type:Journal Article
- Keywords:
Huangqi Guizhi Wuwu Tang;
Drug pairs;
Rule of compatibility;
A nti- Inflammation;
Analgesia
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the anti- inflammatory and analgesic a ctions of Huangqi Guizhi Wuwu Decoction (HGWD) and its compositions and to study its rule of compatibility.Methods Analgesic action of HGWD and its compositio ns were observed by hot- plate method and acetic- acid- induced body twist me thod. Anti- inflammatory action of HGWD and its compositions were observed on t he models of xylene- induced auricular swelling in mice, celiac capillary perme ability in mice, cotton- induced granuloma in rats, albumem- induced arthritis and adjuvant arthritis in rats.Results HGWD and its drug pairs could inhibit the acute inflammation induced by albumen and xylene and rat adjuvant arthriti, decrease the celiac capillary permeability, inhibit the proliferation of granu loma, increase the pain threshold in mice and reduce the frequencies of body tw ist induced by acetic acid.Conclusion HGWD has significant anti- inflammatory and analgesic actions, so does single drug; Radix Astragali alone, but when Ra dix Astragali is used with the other drugs in HGWD, its effect can be enhanced.
