Pharmacokinetic effect of the combination of Fructus Schisandrae and Radix Salvia Miltiorrhizae on schizandrol A and schizandrin B
- VernacularTitle:五味子与丹参配伍对其成分五味子乙素、醇甲的药代动力学影响
- Author:
Shengchun WANG
;
Huiping ZHAO
;
Mengjun HUANGFU
;
Xiaowei LI
;
- Publication Type:Journal Article
- Keywords:
pharmacokinetics;
schizandrol A;
schisandrin B;
schisandra Chinensis
- From:
Chinese Traditional Patent Medicine
1992;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the biopharmaceutical character of the combination of Fructus Schisandrae and Radix Salvia Miltiorrhizae. METHODS: Mice were divided into four group according to schizandrol A, Schizandrin B, Fructus Schisandrae and combination with Radix salvia Miltiorrhizae and then perfused. Mouse's bood plasma was collected in sequence, and the test solusion was prepared by adding amine sulfate and the mixture of acetonitrile methanol (4∶1). Its contents were measure by HPLC in the aid of SIP and 3p97 program. RESULTS: Metabolic rate in mouse of schizandrol A and schizandrin B from combination is apparently lower than that of non combination. CONCLUSION: Chinese Traditional medicinal combination has its biopharmaceutical value.
