Influence of ginkgolides on expression of iNOS in MCAO rats
- VernacularTitle:银杏内酯对大脑中动脉阻塞大鼠脑内iNOS表达的影响
- Author:
Jun REN
;
Zhengping JIA
;
Ruxue ZHANG
;
Huiping MA
;
- Publication Type:Journal Article
- Keywords:
ginkgolides;
cerebral ischemia;
iNOS;
rat
- From:
Chinese Traditional Patent Medicine
1992;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the influence of ginkgolides on expression of inducible nitric oxide synthase (iNOS) in rats. METHODS: Middle cerebral artery occlusion(MCAO) model was induced by ligating internal carotid artery of Sprague Dawley(SD) rats.In this model,the behavioral deficits performance of SD rats was analyzed after given ginkgolides and nimo dipin, respectively, and iNOS gene expression changes in MCAO group were investigated. RESULTS:The expression of iNOS was increased in MCAO models and inhibited in ginkgolides groups. CONCLUSION:Ginkgolides have inhibitive efficacy of iNOS on cerebral ischemia and can reduce brain damage.
