Effect of Changankang Capsule on inflammation and immune function in mice
- VernacularTitle:肠安康胶囊对小鼠炎症和免疫功能的影响
- Author:
Xiankun WANG
;
Xiaohe ZHENG
;
Jianfeng XING
;
Jiayu HOU
;
- Publication Type:Journal Article
- Keywords:
Changankang;
acute inflammation;
delayed type hypersensitivity;
cytokine
- From:
Chinese Traditional Patent Medicine
1992;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of Changankang Capsule (Radix Astragali, Rhizoma Coptidis, Flos Lonicerae, etc.) on acute inflammation and immune function in mice. METHODS:Swelling ears induced dimethylbenzene and capillary vessel increase permeability induced by acetic acid, 2,4 diniitrofluorobenzene (DNFB) induced delayed type hypersensitivity (DTH) was adoptedas mouse model. extent of swelling ears, lymphocyte proliferation and the Tumor necrosis factor ? and interleukin 1 ? in serum were observed. RESULTS:Changankang had significantly anti inflammation in mouse's acute inflammatory model and could inhibit swelling ears and lymphocyte proliferation, decreased the level of TNF ?, but made little iufluence on IL 1? change. CONCLUSION:Changankang Capsule has the effect on anti inflammation and inhibitory effect on the DTH. Its action mechanism may be related to the inhibition of the production of TNF ?.
