Effect of hyperbaric oxygen on the expression of GAP-43 in the spinal cord of rats underwent spinal cord injury
- VernacularTitle:高压氧对鼠损伤脊髓内神经生长相关蛋白表达的影响
- Author:
Gang WANG
;
Shiqing LIU
;
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Spinal cord injury;
GAP-43
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of hyperbaric oxygen (HBO) on expression of GAP 43 in the rats spinal cord following spinal cord injury (SCI). Methods Fifty five Wistar rats were randomly divided into three groups: a normal group, a control group and a HBO treatment group. The rats in the control and HBO treatment group underwent SCI by 10g?5cm impact at the T10 level. The rats in the HBO treatment group were treated by HBO. Western blot was used to observe the change of expression of GAP 43. Results There was weak expression of GAP 43 in the normal spinal cord. The GAP 43 expression increased significantly following SCI. The level of GAP 43 expression in the HBO treatment group was significantly high than that in the control group. Conclusion HBO can increase the level of GAP 43 expression.
