Effect of Wujibaifeng Pills on osteoporosis of ovariectonmized rat
- VernacularTitle:乌鸡白凤丸对去卵巢大鼠骨质疏松症的影响
- Author:
Liying NIU
;
Xinguo WANG
;
Yuping YAN
;
Xia BAI
;
Qiuhong GUO
;
- Publication Type:Journal Article
- Keywords:
Wujibaifeng Pills;
osteoporosis;
bone density;
estradiol;
rat
- From:
Chinese Traditional Patent Medicine
1992;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate effect of Wujibaifeng Pills (WJBFP) on osteoporosis of ovariectonmized (OVX) rat. METHODS: Ovariectonmized (OVX) rat model was established to evaluate osteoporosis of which parameters investigated included bone gla protein (BGP), alkaline phosphatase (ALP), bone minera density (BMD), Serum phosphorus and serum total calcium. RESULTS: WJBFP(1.0g/kg,2.0g/kg,4.0g/kg) could enhance the contents of serum estradiol and calcitonin, decrease serum BGP level in OVX rats; It had no effect on serum total calcium and ALP activities but increase level of serum phosphorus; It could enhance BMD, prevent OVX rat from decreasing bone loss without raising body weight; furthermore, it could inhibit both the uterus and adrenal gland atrophy. CONCLUSION: WJBFP might have better prevention on osteoporosis of ovariectionmized rats.
