Effects of exercise on cell adhesion molecules and cytokines of patients with dyslipidemia
- VernacularTitle:运动锻炼对血脂异常患者血清黏附分子、细胞因子水平的影响
- Author:
Danan LIU
;
Zuoyun HE
;
- Publication Type:Journal Article
- Keywords:
Exercise;
Dyslipidemia;
Cell adhesion molecules;
Cytokines
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of exercise on serum soluble cell adhesion molecules and cytokines of patients with dyslipidemia. Methods Eighty patients with dyslipidemia were randomly and equally divided into an exercise group and a control group. The control group was treated with pravastatin,while exercise was administered in the exercise group in addition to the pravastatin. Both groups were observed for 8 weeks. Results Serum leves of soluble endothelial leucocyte adhesion molecule 1(sELAM),soluble intercellular adhesion molecule(sICAM 1)and interleukin 1?(IL 1?)of patients in both groups were decreased significantly. Moreover,serum levels of soluble vascular cell molecule 1(sVCAM 1)and tumor necrosis factor ?(TNF ?)in addition to sELAM,sICAM 1 and IL 1? were decreased significantly in the exercise group,with a significantly better result in the exercise group as compared with that of the control group. Correlation analysis revealed a positive correlation of individual sELAM,sICAM 1 and sVCAM 1 with blood total cholesterol(TC),and negative correlation of individual sELAM,sICAM 1 and sVCAM with high density lipoprotein cholesterol(HDL C)in exercise group. Conclusion Adequate exercise has beneficial effects on patients with dyslipidemia by reducing serum levels of soluble adhesion molecules and the production of proinflammatory cytokines,which was realized possibly through modulating serum lipids and improving endothelial dysfunction.
