Study of related factors of the therapeutic efficacy of chemonucleolysis under X-ray monitoring for treatment of lumbar disc herniation
- VernacularTitle:椎间盘内注射胶原酶治疗腰椎间盘突出症的影响因素分析
- Author:
Junmin WANG
;
Shanshan ZHU
;
Chuanbing YU
;
Zhangxian NIE
;
- Publication Type:Journal Article
- Keywords:
Collagenase;
Lumbar disc herniation;
Chemonucleolysis
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the related factors of intradiscal injection of collagenase. Methods One hundred and sixty eight patients with lumbar disc herniation were injected with collagenase(600U) under X ray monitoring. Assessment of efficacy of the treatment was made in 1 week, 3 months and 1 year follow up. The parameters such as the size, the type and the number of herniated disc were studied. The effect of stenosis was also analyzed. Results The overall success rate after 1 week, 3 months and 1 year following the therapy was 22.62%, 89.29% and 92.26% , respectively. Seven patients were treated with surgical operation during the follow up, 1 developed cauda equina syndromes at the third day after the injection. It was found that the size of herniation did not affect the efficacy of the treatment. The protruded disc got better result than bulge disc after 1 week following the chemonucleolysis ( P
