Effects of cytochrome P450 2C19 genetic polymorphism on the pharmacokinetics and pharmacodynamics of rabeprazole in Chinese
- VernacularTitle:细胞色素P4502C19基因多态性对雷贝拉唑药动学和药效学的影响
- Author:
Jianming XU
;
Yongmei HU
;
Qiao MEI
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Cytochrome P450;
Genetic polymorphism;
Rabeprazole;
Pharmacokinetics;
Pharmacodynamics
- From:
Chinese Journal of Digestion
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
4 time percentage of 24 h were observed among the three different genotype groups after a single dose or repeated doses of rabeprazole. And the ratio of these pH dates between day 1 and day 8 ranged from 85% to 110%.Conclusions In Chinese healthy Han people, CYP 2C19 genetic polymorphism has not any significant influence on acid inhibitory efficacy and the metabolism of rabeprazole. Rebeprazole could rapidly achieved maximum acid inhibitory efficacy in the subjects with different CYP2 C19 genotype status.
