Effect of ginsenoside Rg_2 on cardiac hemodynamics of anesthetized open chest dog
- VernacularTitle:人参皂苷Rg_2对麻醉开胸犬血流动力学的影响
- Author:
Wenjuan SUN
;
Jie LIU
;
Yiwei LU
;
Jianmin TIAN
;
Longyun LI
;
- Publication Type:Journal Article
- Keywords:
ginsenoside Rg 2;
anesthetized open chest dog;
cardiac hemodynamics;
cardiac function;
blood circulation
- From:
Chinese Traditional Patent Medicine
1992;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of ginsenoside Rg 2 on cardiac hemodynamics in dog. METHODS: The parameters of cardiac hemodynamics were determined by using anesthetized open chest dog. RESULTS: In dogs treated with ginsenoside Rg 2 in a dose of 0.5、 1.0、2.0mg?kg -1 respectively, the heart rate (HR) slowed, the diastolic blood pressure (DBP)、 left ventricular systolic pressure (LVSP) and maximum decreasing rate ( dp/dtmax) increased; the cardiac output (CO)、 cardiac index (CI) and stroke index (SI) decreased; The coronary vascular resistance (CVR)、 the renal vascular resistance (RVR) and total periphery resistance (TPR) increased. CONCLUSION: Effect of ginsenoside Rg 2 on cardiac hemodynamics in dogs is similar to strophanthin K(SK), and can support the blood circulation of important organs.
