Active components of Polysaccharide of Ophiopogon Japonicus on acute myocardial ischemia
- VernacularTitle:麦冬多糖中抗急性心肌缺血活性部位研究
- Author:
Desheng XU
;
Yi FENG
;
Yuehua ZHOU
;
Xiaochen ZHANG
;
Xiao LIN
;
Hailin DENG
;
- Publication Type:Journal Article
- Keywords:
polysaccharide of Ophiopogon Japonicus;
anti myocardial ischemia
- From:
Chinese Traditional Patent Medicine
1992;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To choose the anti myocardial ischemic ingredients from polysaccharide of Ophiopogon Japonicus(PO), then to confirm their effects. METHODS: According to molecular weight, PO was separated to three portions by using ultrafiltration technique. The effects of each separated portion on myocardial ischemia induced by isoproterenol were studied. Then the effects of PO active portions (POAP) on the convulsion of coronary artery induced by pituitrin and acute myocardial ischemia caused by the ligation of coronary artery were further studied in rats. RESULTS: POAP could resist the elevation of Tand S T phase induced by pituitrin in rats, remarkably decrease the elevated S T phase and contents of CK and LDH in serum caused by the ligation of rat coronary artery. POAP also exerted some inhibition effects on the reduction of SOD and increase of MDA caused by myocardial ischemia. CONCLUSION: POAP can protect myocardial cells, inhibit the generation of free radicals, and scavenge the oxygen free radicals generated from myocardial ischemia.
