PDTC reduces E-selectin expression on hypoxia/reoxygenation-stimulated endothelial cells
- VernacularTitle:缺氧-再给氧时PDTC对血管内皮细胞选择素E表达的作用
- Author:
Lixin ZHENG
;
Qi AN
;
Yingkang SHI
;
- Publication Type:Journal Article
- Keywords:
Myocardial reperfusion injury Cell hypoxia E-selectin NF-?B PDTC
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the mechanisms and treatment of ischemia/reperfusion injury. Expression of E selectin was measured and the effect on suppression of E selectin by the Pyrrolidine Dithiocarbamate was investigated. Methods: Endothelial cells were exposed to hypoxia, then returned to reoxygenation condition. ELISA methods were used to detect expression of E selectin. Results: E selectin expression on hypoxia/reoxygenation stimulated endothelial cells increased, PDTC could suppress translation of E selectin effectively. Conclusion: It seems that E selectin may act as a critical factor. PDTC may prove beneficial in the treatment of ischemia/reperfusion injury.
