The Effects of Taurine and ??-alanine on Blood Glucose and Blood Lipid Concentrations in Insulin-treated Diabetic Rats.
- Author:
Kyung Ja CHANG
1
Author Information
1. Department of Food and Nutriton, Inha University, Inchon, Korea.
- Publication Type:Original Article
- Keywords:
diabetes;
insulin;
taurine;
B-alanine;
blood glucose;
blood lipids
- MeSH:
Abdominal Wall;
Animals;
beta-Alanine;
Blood Glucose*;
Body Weight;
Cholesterol;
Diabetes Complications;
Diet;
Drinking;
Drinking Water;
Eating;
Glucose Tolerance Test;
Humans;
Insulin;
Insulin, Isophane;
Male;
Plasma;
Rats*;
Rats, Sprague-Dawley;
Streptozocin;
Taurine*;
Vascular Diseases
- From:Korean Journal of Community Nutrition
1999;4(1):103-110
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The purpose of this study was to determine the effects oftaurine supplementation and taurine depletion on blood glucose and blood lipid concentrations in insulin-treated diabetic rats. Four groups of Sprague-Dawley male rats were fed the purified diet for 3 weeks ; nontaurine-supplemented diabetic rats(E0), nontaurine-supplemented diabetic rats with insulin treatment(E0+I), 1% taurine-supplemented diabetic rats with insulin treatment(E1+I) and taurine-depleted diabetic rats with insulin treatment(EA+I). Diabetes was induced by streptozotocin injection(50mg/kg B.W.). Isophane insulin was given subcutaneously into the abdominal wall of the diabetic rats(4 unit/rat/day). E1+I were supplemented with 1% taurine in drinking water. To induce taurine depletion, EA+I were treated with 5% beta-alanine in drinking water. E1+I had significantly higher body weight compared to that fo E0. The food intakes of E1+I and E0+I were significantly decreased compared to that of E0. There was no sigfniciant difference in food intake between E1+I and E0+I. The water intake of rats was significantly different among the groups ; E0>E0+I>E1+I>EA+I. The urine volume of E0 was significantly increased compared to those of insulin-treated goups. The blood glucose concentration of E0 was significantly increased compared to those of insulin-treated groups. In the oral glucose tolerance test(OGTT), E0+I and E1+I had significantly lower blood blucose concentrations compared to E0 after 30 min. Also EA+I had significantly lower bloodglucose concentrtion compared to E0 and E0+I. The plasma total cholesterol and LDL-cholesterol concentratons of EA+I were significantly incrased compared to those of other groups. Therefore, it may be suggested that tuarine supplementation is useful for insulin-dependent diabetes in order to prevent diabetic complications suchas cardiac vascular diseases.
