Expression of L-selectin in rat models undergoing cardiopulmonary bypass and the pulmonary protective effect of its antagonist
- VernacularTitle:L-选择素在体外循环中的表达及其拮抗剂的肺保护作用
- Author:
Jinrong XUE
;
Yinglong LIU
;
Qiang WANG
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
L-selectin Reperfusion injury Lung Fucoidin
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2003;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the expression of L selectin and its possible role in pulmonary injury in rat models undergoing cardiopulmonary bypass (CPB) and to investigate the protecive effect of fucoidin during the procedure. Methods: Models of CPB and pulmonary perfusion in rats were used to investigate the expression of L selectin pre and post operation. Its expression in antagonist group was also studied. Other indexes, including the concentration of SOD, MDA and MPO in rat lung tissues as well as PaO 2/FiO 2 and histological changes, were studied to illustrate the possible mechanism of L selectin in lung reperfusion injury. Results: The expression of L selectin increased after creating CPB but decreased after pulmonary infusion with fucoidin during the procedure, and lung injury relieved as well. Conclusion: L selectin might lead to lung injury during CPB, blocking its expression may relieve lung injury and enhance the recovery of lung function.
