Expression of TGF-?1 protein and its significance in colorectal carcinoma tissues
- VernacularTitle:TGF-?1蛋白在大肠癌组织的表达及意义
- Author:
Hua TANG
;
Caiquan ZHANG
;
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Transforming growth factor ?1
- From:
Journal of Chongqing Medical University
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of TGF-?1 and its clinical significance in colorectal carcinoma(CRC).Methods:The expression of TGF-?1 in seventy patients with CRC and 10 normal colorectal mucosal tissues were examined by immunohistochemistry,and the expression of TGF-?1 was analyzed with relation to clinicopathologic factors and post-operative survival.Results:Compared with the normal colorectal mucosal tissues,the expression of TGF-?1 in CRC was higher.The overexpression of TGF-?1 is associated with lymph node metastasis,Dukes staging and poor prognosis in patients with CRC.Conclusion:TGF-?1 stimulates CRC cells infiltration and metastasis.The expression of TGF-?1 appears to be a new prognostic factor for the prediction of outcome in patients with CRC.
