Effect of Jiedu Lifei Oral Liquid on Immune Function in Mice with Viral Pneumonia
- VernacularTitle:解毒利肺口服液对病毒性肺炎小鼠免疫功能的影响
- Author:
Shide SHI
;
Minwei ZHOU
;
Jianjun LI
;
Wenling ZHENG
;
- Publication Type:Journal Article
- Keywords:
JIEDU LIFEI ORAL LIQUID/ther.use;
PNEUMONIA,VIRAL/TCD therapy;
INTERLEUKIN-1/blood;
INTERLEUKIN-2/blood;
TUMOR NECROSIS FACTOR ?/blood;
INTERFERON ?/blood
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To observe the effect of Jiedu Lifei Oral Liquid (JLOL, mainly composed of Flos Lonicerae,Fructus Forsythiae, Radix Scutellariae, Bulbus Frityllariae, etc. ) on the immune function in mice with viral pniumonia.[Methods] Sixty mice were randomized into 5 groups: normal group (A), model group (B), virazole group (C), small-dose JLOL group (D) and large-dose JLOL group (E). Mouse models of viral pheumonia were induced by infection ofinfluenza virus FM1. Effects of JLOL on serum levels of interleukin-1 (IL-1), interleukin-2 (IL-2), tumor necrosisfactor ? (TNF-?) and interferon ? (IFN-?) were observed. [Results] Compared with normal group, serum levels of IL-1 and (IFN-? were decreased and TNF-? increased (P 0.05 ) in model group.After treatment wth JLOL, serum levels of IL-2 and IFN-? were increased , TNF-? decreased (P 0.05). [ Conclusion] JLOL can increase the immune function by increasing the serumlevels of IL2 and IFN-? and can reduce the immune impairment by inhibiting the over production of TNF-?.
