Studies on mechanism of antihypertension effect of extracts from Compound Jueming
- VernacularTitle:复方决明提取物的降压作用机制研究
- Author:
Suhong CHEN
;
Guiyuan LU
;
Bin SHI
;
Wanli LI
;
Liying ZHANG
;
- Publication Type:Journal Article
- Keywords:
extracts from Compound Jueming (CJ);
hypertension;
angiotensin Ⅱ (ANG Ⅱ);
renin activity (RA);
aldosterone (ALD);
atrial natriuretic polypeptide (ANP);
endothelin (ET)
- From:
Chinese Traditional and Herbal Drugs
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To probe into the antihypertension activity mechanism of extracts from Compound Jueming (CJ). Methods The method of radioimmunoassay was used to assay the concentration of the related substances on spontaneously hypertensive rats (SHR) such as angiotensin Ⅱ (ANGⅡ), renin activity (RA), endothelin (ET), atrial natriuretic polypeptide (ANP), aldosterone (ALD), and urine. Results All of the three doses (9.5, 7.2, and 4.8 g/kg) of extracts from CJ reduced ANG Ⅱ and RA, but had no influence on ALD, ET, ANP, and urine in SHR. Conclusion The antihypertension effect of extracts from CJ is related to decreasing of renin angiotensin, but not to ALD, ET, ANP, and urine.
