Antimicrobial Resistance and Serotypes in the Clinical Isolates of Group B Streptococci.
- Author:
Young UH
1
;
In Ho JANG
;
Gyu Yel HWANG
;
Kap Jun YOON
Author Information
1. Department of Clinical Pathology, Yonsei University Wonju College of Medicine, Wonju, Korea. u931018@yonsei.wonju.ac. kr
- Publication Type:Original Article
- Keywords:
Group B streptococci (GBS);
Antimicrobial susceptibility;
Erythromycin resistance;
Clindamycin resistance;
Serotype
- MeSH:
Anti-Infective Agents;
Ceftriaxone;
Chloramphenicol;
Clindamycin;
Drug Resistance, Multiple;
Erythromycin;
Penicillins;
Phenotype;
Strikes, Employee;
Tetracycline;
Vancomycin
- From:Korean Journal of Clinical Microbiology
1999;2(1):64-70
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: This study is designed to provide data on the trend of resistance by year of isolation in the clinical isolates of group B streptococci(GBS) during recent eight years and to elucidate the relationship between serotypes and antimicrobial resistance patterns. METHODS: The minimal inhibitory concentrations (MIC) of seven antimicrobial agents and serotypes for 150 strains of GBS isolated from clinical specimens between 1990 and 1997 were investigated. RESULTS: The resistance rate of 150 clinical isolates of GBS were 20.0% to clindamycin, 16.0% to erythromycin, 4.0% to chloramphenicol, and 95.3% to tetracycline. None was resistant to penicillin, ceftriaxone, or vancomycin. Of the 24 isolates resistant to erythromycin, 20 (83.3%) were resistant to clindamycin. Resistance rates of erythromycin according to serotypes in decreasing order were 69.2% (V), 23.2% (III), and 3.5% (Ib). All serotypes Ia and II were susceptible to erythromycin and clindamycin. CONCLUSIONS: Striking emergence of resistant strains to erythromycin and clindamycin in our clinical isolates of GBS was mainly due to sudden increase of serotype V and III which shows multi-drug resistance phenotype.
