Inhibitory Effect of Danggui Decoction on Passive Cutaneous Anaphylaxis in Mice
- VernacularTitle:当归饮子对小白鼠被动皮肤过敏反应的抑制作用
- Author:
Hongli XIAO
;
- Publication Type:Journal Article
- Keywords:
URTICARIA/TCD therapy;
DANGGUI DECOCTION/ther.use;
PASSIVE CUTANEOUS ANAPHYLAXIS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To explore the mechanism of Danggui Decoction (DD) in counteracting allergic reaction bymeans of passive cutaneous anaphylaxis (PGA) test.【Methods】Among fifty NEH mice, ten were used to prepareantiserum and the rest forty were randomized into 4 groups: normal control group (A), clarityne group (B), low-doseDD group (C) and high-dose DD group (D) . PGA was induced by intraperitoneal injection of antiserum in the fourgroups and the mice were treated with gastric infusion simultaneously. After the last feeding, antigen attack wasconducted. Inhibitory rate of PCA in four groups were measured by colorimetric analysis after treatment. 【Results】High-and low-dose DD and clarityne could inhibit PCA in mice (P0.05).【Conclusion】The anti-allergic effect of DD may be associated with the inhibition of type Ⅰ allergic reaction.
