Study on Gansu Capsule ( sustained release) in pharmacokinetics
- VernacularTitle:肝苏缓释胶囊的药代动力学研究
- Author:
Ming YANG
;
Rongping YANG
;
Qingde HUANG
;
Zhi LI
;
Xiaobing LIU
;
- Publication Type:Journal Article
- Keywords:
Gansu Capsule (sustained release);
Gansu Capsule (common) correlation in vivo and in vitro;
high performance liquid chromatography
- From:
Chinese Traditional Patent Medicine
1992;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: By studying the pharmacokinetics in dogs' vivo of Gansu Capsule (sustained release), evaluate slow release effect in vivo of Gansu Capsule (sustained release). Methods: To take gallic acid as marker component, which is one of effective components, After taking Gansu Capsule (sustained release) and Gansu Capsule (common), to adopt high performance liquid chromatography to determinate the blood concentration of acid pyrogallol in dogs at different time. Results: Both Gansu capsule (sustained release) and Gansu Capsule (common) coincide one compartment model. It suggested that Gansu Capsule (sustained release) had remarkable effects of slow release and could maintain higher blood concentration in vivo longer the slow release effect of Gansu Capsule (sustained release) in vivo that could be evaluated by accumulative releasing percentage in vito. Conclusion: Gansu Capsule (sustained release) had good slow release effect in vivo and vitro.
