Mechanisms of orindonin induced apoptosis on NB_4 cells
- VernacularTitle:冬凌草甲素对NB_4细胞的诱导凋亡机制
- Author:
Jiajun LIU
;
Xinyao WU
;
Xianglin PAN
;
Guiqing CAI
;
- Publication Type:Journal Article
- Keywords:
orindonin;
Caspase3;
apoptosis
- From:
Chinese Traditional Patent Medicine
1992;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the mechanism of orindonin induced apoptosis on NB4 (Human acute promylocytic leukeamia cell line) cells. Methods: The variation of both morphology and inhibitory rate of NB4 cells were observed in culture medium with various concentrations of orindonin at different time in vitro. The activity of Caspase3 was detected before and after apoptosis occurred. Results: orindonin could increase the activity of Caspase3, inhibit the growth and cause apoptosis on NB4 cells significantly. The variations were both in time and dose dependent manner. Conclusion: Orindonin can inhibit the growth of NB4 cells and induce apoptosis. Increasing the activity of Caspase3 may be one of the most important mechanism.
