Significance of antibody against ?-fodrin-derived polypeptide in diagnosis of Sjgren′s syndrome
- VernacularTitle:抗?-胞衬蛋白多肽抗体在干燥综合征诊断中的意义
- Author:
Jing HE
;
Jing LI
;
Zhanguo LI
;
Qiaolin CHEN
;
- Publication Type:Journal Article
- Keywords:
Sjgren′s syndrome;
? fodrin;
Blotting,Western;
Enzyme linked immunosorbent assay
- From:
Chinese Journal of Rheumatology
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the sensitivity and specificity of anti ? fodrin polypeptide antibody in Sjgren′s syndrome (SS) patients.Methods Synthesized ? fodrin polypeptide was used as substrate in enzyme linked immunosorbent assay (ELISA) to detect the specific antibody in sera of SS and other rheumatic diseases.Results Antibody against ? fodrin polypeptide were detected in 73% of patients with primary SS,40% of patients with secondary SS,19 5% of patients with SLE,29 5% of patients with RA,and 3 8% of normal blood donors.The positive rates of ? fodrin polypeptide antibody in primary and secondary SS (73% and 40%,respectively) were significantly higer than those in SLE,RA and normal controls ( P
