Relationship between glucocorticoid-induced osteoporosis and vitamine receptor genotypes
- VernacularTitle:糖皮质激素所致骨质疏松与维生素D受体基因型相关性的初步研究
- Author:
Yuming LI
;
Lin XU
;
Lulu CHEN
;
- Publication Type:Journal Article
- Keywords:
Glucocorticoids;
Receptors,calcitriol;
Osteoporosis;
Genotype;
Polymorphism,restriction fragment length
- From:
Chinese Journal of Rheumatology
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
0 05).Conclusion The distribution frequency of bb type of VDR genotypes in Han populations of China was more prevalent,followed by Bb and bb types in turn.In the patients receiving long term glucocorticoid therapy,there is no significant difference in BMD between Bb and BB genotypes.The data suggest that the VDR genotypes may not be a means to identify patients at great risk of glucocorticoid induced osteoporosis,which await to be further confirmed with a large sample size.
