Anti-endotoxic effects of syringic acid in Radix Isatidis
- VernacularTitle:板蓝根中丁香酸的抗内毒素作用
- Author:
Yunhai LIU
;
Jiangguo FANG
;
Xuepeng GONG
;
Wei XIE
;
- Publication Type:Journal Article
- Keywords:
syringic acid (SA);
anti endotoxin;
Radix Isatidis (BLG)
- From:
Chinese Traditional and Herbal Drugs
1994;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To study the anti endotoxic effect of syringic acid (SA) which was isolated from Radix Isatidis (Banlangen in Chinese, BLG). Methods SA was extracted and isolated from BLG and made to 1% solution. The content of SA pretreated ET was quantitatively determined using Limulus Test. Then the ability of fever induction of endotoxin (ET) pretreated with SA was measured using endotoxin induced fever test in rabbits. At last, the lipopolysaccharide (LPS) induced death in mice pretreated with and without SA was compared. Results Being pretreated with SA, 83.16% ET was destroyed, the ET induced fever in rabbits relieved markedly and the LPS induced death rate in mice dropped from 68% to 20%. Conclusion SA isolated from BLG has anti endotoxic effects.
