Expression of IL-1?,TNF-? and nitric oxide in the cervical intervertebral disc of patients with cervical spondylotic myelopathy
- VernacularTitle:脊髓型颈椎病椎间盘内白介素1?、肿瘤坏死因子?及一氧化氮的表达及其意义
- Author:
Li JIANG
;
Fengying SHI
;
Jianwei XU
;
- Publication Type:Journal Article
- Keywords:
Cervical spondylotic myelopathy;
Cervical disc;
Interleukin 1?;
Tumor necrosis factor ?;
Nitric oxide
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of IL 1?,TNF ? and nitric oxide (NO) in the cervical intervertebral disc and their roles in the pathogenesis of cervical spondylotic myelopathy (CSM). Methods Fifteen cervical discs were obtained from patients of CSM undergoing anterior disc surgery. Six cervical discs specimens were obtained in the surgical operation with patients with traumatic cervical injury served as the control. The specimens were analyzed for IL 1?、TNF ? by use of ELISA method, NO was measured by optical density assays. Results The contents of IL 1?,TNF ? and NO in disc of CSM patients increased significantly when compared with the control group. Conclusion The results of the present study indicated that IL 1?,TNF ? and NO may be involved in the pathogenesis of CSM.
