The role of apoptosis in hepatocyte injury in type Ⅰ autoimmune hepatitis
- VernacularTitle:Ⅰ型自身免疫性肝炎患者肝组织细胞凋亡的研究
- Author:
Xiong MA
;
Dekai QIU
;
Yansheng PENG
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Hepatitis;
Autoimmune disease;
Apoptosis
- From:
Chinese Journal of Digestion
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of apoptosis in hepatocyte injury in tyep Ⅰ autoimmune hepatitis (AIH). Methods Using transferase mediated UTP biotin nick end labling (TUNEL) technique and immunohistochemistry with anti Fas antibody, we detected apoptosis cells in 10 liver biopsy samples and 3 control livers obtained from normal subjects. Result Hepatocytes in all AIH liver tissues were positively stained by TUNEL and anti Fas antibody in various degree. In contrast, control tissues did not show DNA fragmentation or positive stain with anti Fas antibody. A significant correlation was seen between apoptosis index (AI) and necroinflammatory grading ( r =0.45, P
