Study on the effects of Azone on the transdermal kinetics of Resibufogenin
- VernacularTitle:氮酮对蟾酥中蟾毒内酯类成分透皮吸收的影响
- Author:
Shengshan ZHU
;
Zhiping LU
;
Qiang LIU
;
- Publication Type:Journal Article
- Keywords:
Resibufogenin;
Azone;
transdermal enhancers
- From:
Chinese Traditional Patent Medicine
1992;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of Azone on the transdermal kinetics of Resibufogenin from toad venom. Methods: The transdermal constants of Resibufogenin var hairless mice skin are determined with various concentration of Azone as transdermal enhancers. Results: The transdermal constants are 81.25, 114.92, 169.63 , 196.31, 208.27, 261.35 (?g/cm 2?h) while the concentration of Azone are 0%, 2%, 4%, 6%, 8%, 10%, respectively. Conclusion: Azone can enhance Resibufogenin penetrate skin and the optimum concentration of Azone is 10%.
