Association of killer cell immunoglobulin-like receptor gene polymorphisms with seronegative spondylarthropathies
- VernacularTitle:杀伤细胞免疫球蛋白样受体基因多态性与血清阴性脊柱关节病的关联性研究
- Author:
Weijuan GONG
;
Jueqin YANG
;
Lei ZHANG
;
Fangjuan YAO
;
Lian FAN
;
- Publication Type:Journal Article
- Keywords:
Genes;
Joint diseases;
Genotype;
Haploidy
- From:
Chinese Journal of Rheumatology
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether the killer cell immunoglobulin like receptor (KIR) gene polymorphisms are associated with seronegative spondylarthropathies.Methods All 197 HLA B27 positive patients with seronegative spondyloarthro pathies (SpA) and 83 randomly ethnically matched healthy controls were enrolled to detect the KIR genotype using PCR SSP in Shanghai area.Results The KIR3DL1 gene frequency was significantly lower in the patient group (0 763) than in the control group (1 00) (RR=0 76, P =0 003).Meanwhile,the gene frequencies of two pseudogenes (KIR2DP1,KIR3DP1) were significantly higher in SpA group than in healthy control group (RR=1 1, P =0 004).Conclusion There may be a negative association between pathogenesis of SpA and KIR3DL1 gene.The function of KIR3DL1 molecule should be investigated deeply.
