Effect of total alkaloids in Equisetum pratense on activity of MAO-B in mice brain
- VernacularTitle:草问荆总生物碱对小鼠脑单胺氧化酶-B活性的影响
- Author:
Yubin JI
;
Shiyong GAO
;
- Publication Type:Journal Article
- Keywords:
total alkaloids of Equistum pratense Ehrh. (TAEP);
monoamine oxidase B (MAO B);
inhibitory action on CNS
- From:
Chinese Traditional and Herbal Drugs
1994;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To study the effects of total alkaloids in Equisetum pratense Ehrh. (TAEP) on the activity of monoamine oxidase B (MAO B) in mice brain, to reveal the mechanism of its inhibitory action on the central nervous system (CNS). Methods The activity of MAO B was determined by UV spectrophotometry. Results TAEP can markedly activate MAO B in cerebrum and antagonise the inhibition of MAO B activity by nialamide. Conclusion TAEP is a MAO B agonist with an action for the evacuation of monoamine, this may be considered as one of the mechanisms of TAEP sedative and tranquilizing action on CNS.
