Synchro-determination of borneol and tetramethyl pyrazine in plasma by GC-FID for volunteers administrated with Suxiao Jiuxin Wan
- VernacularTitle:GC-FID法同步测定人含服速效救心丸后血中冰片、川芎嗪含量
- Author:
Jun GUO
;
Xi HUANG
;
Lili WANG
;
Hua MENG
;
Li ZHANG
;
Ping REN
;
- Publication Type:Journal Article
- Keywords:
borneol;
tetramethyl pyrazine (TMP);
GC FID;
parmacokinetics
- From:
Chinese Traditional and Herbal Drugs
1994;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To develop a method for pharmacokinetics detection of chemical component in healthy volunteers' plasma administrated with Suxiao Jiuxin Wan, to provide the clinical experimental evidences for therapeutic drug monitoring (TDM) and the hypothesis of pharmacokinetics of traditional Chinese syndrome and recipe. Methods A GC FID method was established for rapid determination of borneol, tetramethyl pyrazine (TMP) content in healthy volunteers' plasma. After obtaining the blood sample at different time, the plasma concentration of borneol, TMP was detected, respectively. The data were processed with the software 3P97 to calculate the pharmacokinetics parameters. Results A good linear relationship of borneol, TMP existed in the plasma of healthy persons in the range of 20-420 ng/mL. Whole blood concentration time course of borneol and TMP in the group administrated with Suxiao Jiuxin Wan was fitted to be a one compartment model. Borneol and TMP in healthy persons were absorbed, distributed and excreted rapidly. Conclusion The GC FID method is sensitive, reliable and rapid, it can be used in pharmacokinetics study of borneol and TMP in vivo.
