Effects of pulmonary artery perfusion with hypothermic protective solution on pulmonary vascular endothelial cell injury during cardiopulmonary bypass
- VernacularTitle:肺动脉灌注低温保护液对肺血管内皮损伤的保护作用
- Author:
Bo WEI
;
Yinglong LIU
;
Cuntao YU
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Cardiopulmonary bypass Endothelium,vascular Perfusion,regional
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the effects of hypothermic protective solution perfusion to pulmonary artery on lung vascular endothelial cell injury during cardiopulmonary bypass. Methods: 64 children with tetrogy of Fallot were randomly divided into lung protect group (n=34) and control group (n=30). The way of lung protection was to perfuse with hypothermic protective solution to pulmonary artery. Routine approach was used in control group. Plasma ET and vWF were measured. Lung biopsy specimens were obtained at end of operation in order to study histological changes of lung vascular endothelium. The expression of ICAM 1 on lung vascular endothelium was detected. Patients' hemodynamics and lung functions were monitored. Results: ET and vWF were lower in lung protect group when compared with control group at 0 hour after operation (P
