THE AMPLIFICATION AND EXPRESSION OF c-erbB2 AND p53 IN ORAL SQUAMOUS CELL CARCINOMAS
- VernacularTitle:口腔鳞癌中c-erbB2和p53基因的扩增和表达
- Author:
Naiguo LIU
;
Shuhua WU
;
Changmin SHAN
;
Zenghua LU
;
Jie ZHANG
;
- Publication Type:Journal Article
- Keywords:
Oral squamous cell carcinoma;
In situ hybridization;
Image analysis;
Gene amplification;
Gene expression
- From:
Acta Anatomica Sinica
1957;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
0 05); The protein expression of erbB2 in carcinomas of palate and floor of mouth were obviously higher than the expression in lip cancer and gingival carcinoma( P 0 05).Conclusion The amplification and overexpression of c erbB2 and p53 play important roles in the formation and development of OSCC, the overexpression of c erbB2 protein has more important significance in tumorigenesis of carcinomas of palate and floor of mouth; Not only transcriptional regulation but also translational modulation exists on the expression of c erbB2 and p53. [
