Expression of leptin and long form of leptin receptors messenger ribonucleic acid and protein in endometrium of patients with polycystic ovary syndrome
- VernacularTitle:瘦素及瘦素长受体在多囊卵巢综合征患者子宫内膜的表达
- Author:
Yuzhen WANG
;
Jie QIAO
;
Lili LIU
;
Yongjian CHEN
;
Meizhi LI
;
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Endometrium;
Leptin;
Carrier proteins
- From:
Chinese Journal of Obstetrics and Gynecology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of leptin and long form of leptin receptors (Ob R L) messenger ribonucleic acid (mRNA) and protein in endometrium during mid luteal phase of patients with polycystic ovary syndrome (PCOS) Methods The expession of leptin and Ob R L mRNA in endometrium during mid luteal phase from 15 normal controls and 14 PCOS related anovulatory patients who underwent ovulation induction therapy were studied by in situ hybridization, and levels of leptin and Ob R L protein were investigated by immunohistochemical methods Results The expression of Ob R L mRNA and protein in endometrial glands of most patients with PCOS were weak or moderate positive,whereas the levels of Ob R L mRNA and protein were moderate or strong positive in those of the controls,there was significant difference between the two groups; leptin mRNA and protein expression in enodmetrium of patients with PCOS and controls were not significantly different between the groups Conclusion The expression of Ob R L decreased in endometrium of mid luteal phase in patients with PCOS during induced ovulation,which may be related to low pregnancy rate of patients with PCOS.
