Pharmacological Action of Polysaccharides from Radix Codonopsis on Immune Function and Hematopoiesis in Mice
- VernacularTitle:党参多糖对小鼠免疫和造血功能的影响
- Author:
Xiaojun ZHANG
;
Chenchen ZHU
;
Li HU
;
Xiaoping LAI
;
Jianxia MO
;
- Publication Type:Journal Article
- Keywords:
Polysacchrides from radix codonopsis/pharmacology;
Polysacchrides from radix codonopsis/immunology;
Hematopoietic system/drug effects;
Administration,Oral
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influences of polysacch arides(PS)from Radix Codonopsis on immune function and hematopoiesis in mice.Methods Several experiments have been condu cted for detecting delayed type hypersensitivity(DTH),hemolysin antibody concentration,endogenous spleen colony,3 H-TdRpermeate nuleated cells in bon e marrow.Results By oral administration,PS from Radix Codonopsis can promote the humoral immunity and PS at a small dosage en-hance the cellular immunity.PS from Radix Codonopsis can also elevate the hemoglobin cont ent of the hemolysis -induced blood -deficiency mice and increase the formation of endogenous spleen c olony,but has less effect on DNA synt hesis in the bone marrowof blood -deficiency mic e caused by 60 Co -?ray.Conclusion PS from Radix Codonopsis can enhance the im-mune function and improve the compen satory hematopoiesis of spleen and t heir mechanisms need to be further studied.
