THE STUDY OF TELOMERASE DURING DMBA INDUCING WISTAR RAT BREAST CANCER
- VernacularTitle:7,12-二甲基苯丙蒽诱导Wistar大鼠乳腺癌发生过程中端粒酶活性变化
- Author:
Dachuan LIU
;
Huanjiu XI
;
Fei LI
;
Jiabang SUN
;
- Publication Type:Journal Article
- Keywords:
DMBA;
Breast cancer;
Telomerase;
Apoptosis
- From:
Acta Anatomica Sinica
1955;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The changes of telomerase activity were dynamically observed after DMBA was used to induce breast cancer in Wistar rats. Methods Apoptosis was determined quantitatively by TUNEL,and telomerase activity was detected by RT PCR ELISA method. Results Telomerase activity was gradually increased after breast cancer occurred.Conclusion\ As breast cancer occurred,the telomerase activity gradually increased while apoptosis decreased.Telomerase could be a useful marker for diagnosis of the breast cancer.\;[
