THE DISTRIBUTION DIFFERENCE BETWEEN Mel 1a AND Mel 1b MELATONIN RECEPTORS IN THE CENTRAL NERVOUS SYSTEM OF RATS
- VernacularTitle:褪黑素受体亚型Mel1a和Mel1b在大鼠中枢神经系统的分布差异——原位杂交研究
- Author:
Haiwei XU
;
Haidi LI
;
Xuan WU
;
Xiaotang FAN
;
Fayun GONG
;
- Publication Type:Journal Article
- Keywords:
Melatonin receptor;
Central nervous system;
In situ hybridization;
Rat
- From:
Acta Anatomica Sinica
1954;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To exam the expression and the distribution difference between melatonin membrane receptor subtype Mel 1a and Mel 1b in the central nervous system of rats. Methods In situ hybridization technique was used. Results (1)The Mel 1a mRNA positive cells were mainly detected in the hippocampus,cerebral cortex,supraoptic nucleus,paraventricular nucleus,suprachiasmatic nucleus,inferior olivary nucleus,cortex and fastigial nucleus of cerebellar,ventral horn of the spinal cord,facial nerve nucleus,gigantocellular reticular nucleus,striatum cortex and trigeminal nerve nucleus,etc.(2)The Mel 1b mRNA positive cells were mainly observed in the cerebellar cortex,fastigial nucleus,global nucleus,emboliform nucleus of the medullaris cerebelli,hippocampus,cerebral cortex,ventral horn of the spinal cord,supraoptic nucleus and suprachiasmatic nucleus.Conclusion\ Mel 1a mRNA positive neurons were abundant and distributed widely in the CNS,while Mel 1b mRNA\|positive neurons distributed comparatively localized.However,the hippocampus and the cortex were two regions which were rich in both Mel 1a and Mel 1b mRNA positive neurons.\;[
