AN ULTRASTRUCTURAL STUDY ON EFFECT OF HYPOXIC PULMONARY VASCULAR IN YOUNG RATS BY HEME-OXYGENASE/CARBON-MONOXIDE SYSTEM
- VernacularTitle:CO/HO体系影响缺氧性肺动脉高压幼年大鼠肺动脉超微结构的研究
- Author:
Lin SHI
;
Heping ZENG
;
Xiuying TANG
;
Junbao DU
;
- Publication Type:Journal Article
- Keywords:
Pulmonary artery;
Hypoxia;
Carbon monoxide;
Young rat
- From:
Acta Anatomica Sinica
1954;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of hemeoxygenease/carbon monoxide system on hypoxic pulumonary vascular structural remodeling. Methods Twenty six Wister rats were randomly divided into four groups:control groups( n =6),hypoxia group( n =7),hypxia+ZnPP group( n =6) and hypoxia+CO group( n =7).Pulmonary artery mean pressure(mPAP) of each rat was elaluated by using right cardiac catheterization,the ultrastructaral changes in intra acinar pulmonary muscularized arteries were observed. Results mPAP was significantly increased in hypoxic rats(22?2 31?mmHg)as compared with that of normal controls(16 57?2 51mmHg)( P
