THE EFFECTS OF PRENATAL COCAINE EXPOSURE ON THE DEVELOPMENT OF OFFSPRING’S BRAINS:MORPHOLOGIC STUDY
- VernacularTitle:妊娠中晚期暴露于可卡因对后代脑发育影响的形态学观察
- Author:
Xiaowei GUAN
;
Jun SONG
;
Wei HE
;
Jiaqian REN
;
- Publication Type:Journal Article
- Keywords:
Cocaine;
Pregnancy;
Cerebral cortex;
Corpus callosum;
Hippocampus;
Neuron;
Astrocyte;
Mice
- From:
Acta Anatomica Sinica
1954;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of prenatal cocaine exposure on the development of offspring's brains by building a murine model. Methods We weighted the body weight and brain weight of offspring on P10 from COC and SAL groups and observed the development of neuron and astrocyte in cerebral cortex by toluidine blue staining and immunohistochemistry. Results The brain weight and body weight from COC were both reduced on P10 compared with SAL group.We discovered prenatal cocaine exposure induced polarity disorder and dysplasia of neuron in cerebral cortex;the number of the astrocytes in corpus callosum and hippocampus regions decreased.Conclusion\ Pregnatal cocaine exposure can result in abnormal development of cerebral cortex of offsprings which may play an important role on cocaine induced abnormal behavior.\;[
