EFFECTS OF IN UTERO EXPOSURE OF TCDD ON SYNTHESIS OF EPIDERMAL GROWTH FACTOR AND EPIDERMAL GROWTH FACTOR RECEPTOR IN SUBMANDIBULAR GLAND OF RAT OFFSPRINGS
- VernacularTitle:孕期四氯二苯对二噁英处理对子鼠颌下腺表皮生长因子和表皮生长因子受体的影响
- Author:
Xiaoning HAN
;
Xiaohan WANG
;
Wei HE
;
- Publication Type:Journal Article
- Keywords:
TCDD;
Submandibular gland;
EGF;
EGFR;
Rat
- From:
Acta Anatomica Sinica
1954;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of in utero exposure of TCDD on synthesis of EGF and EGFR in submandibular gland of rat offspring. Methods SD rats were treated with TCDD 5??g/kg on Day 15 of gestation, the expression of EGF and EGFR in submandibular gland of rat offspring were analyzed by immunohistochemistry method. Results On PND32 and PND49, the expression of EGF and EGFR in TCDD experiment group were more than that of control group, the difference was statistically significant.Conclusion In utero exposure of TCDD can promote the synthesis of EGF and EGFR in submandibular gland of rat offspring from prepuberty stage through puberty stage. [
