Relationship between abnormal expression of E-cadherin-catenin complex in gastric carcinoma and its clinicopathological features as well as patient survival
- VernacularTitle:E-钙粘蛋白-连接素复合体表达与胃癌临床病理学及生存期的关系
- Author:
Yongning ZHOU
;
Caipu XU
;
Guiyong PENG
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
E cadherin catenin complex;
Immunohistochemistry;
Gastric carcinoma;
Clinicopathology;
Survival
- From:
Chinese Journal of Digestion
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective E cadherin catenin complex mediates cell cell adhesion and plays an important role in maintaining normal architecture and function of epithelial tissues. We evaluated the expression patterns of E cadherin, ? catenin, and ? catenin in gastric carcinoma and determine the potential relationship between E cadherin catenin complex and tumor clinicopathological features as well as patient survival. Methods Immunohistochemical staining of E cadherin, ? catenin, and ? catenin in 148 gastric carcinomas was performed. Results The abnormal expression rates of E cadherin, ? catenin and ? catenin in the tissues of gastric carcinomas were 44.6%, 73.6% and 43.2%, respectively. The total abnormal expression rate of E cadherin complex in 148 cases of gastric carcinoma was 91.9%. Reduced expression of E cadherin, ? catenin and ? catenin were significantly correlated with tumor differentiation status ( P
