Systemic lupus erythematosus complicated with Pneumocystis carinii pneumonia
- VernacularTitle:系统性红斑狼疮并发卡氏肺孢子虫肺炎二例并文献复习
- Author:
Guoqiang CHEN
;
Hongwei ZHANG
;
Qiaohong ZHAO
;
Juquan ZHAO
;
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Pneumonia, Pneumocystis carinii;
Pneumocystis carinii
- From:
Chinese Journal of Rheumatology
2002;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical manifestation of systemic lupus erythematosus (SLE) complicated with Pneumocystis carinii pneumonia (PCP).Methods Retrospective analysis of the clinical data of two cases of SLE complicated with PCP.Results The two patients were both aged 31 years and have had SLE disease for 4 and 7 years respectively.Both had lupus nephritis and were previously treated with high dose corticosteroid and cyclophosphadmide.Both patients had ceased immunosuppressive drug treatment for 6 and 12 months respectively at the time of diagnosis of PCP infection.Both patients presented with acute fever with dry cough,shortness of breath at rest,progressive hypoxia and diffuse reticular shadows on chest X ray. Pneumocystis carinii were identified in the bronchoalveolar lavage fluid (BAF) in both cases.SMZ was used to treat the PCP infection.The first patient recovered with improvement in her clinical well being and chest X ray appearance,while the second failed to respond and eventually succumbed.Conclusion One should be alert to the occurrence of PCP when patients with SLE present with rapidly progressive hypoxemia and type I respiratory failure.The mortality rate is high in SLE patients complicated with PCP and early diagnosis and treatment are the key to improving survial in these patients.Recurrence of PCP is common and adequate duration of treatment is essential.
