Acute toxicity and antithrombotic effect of Xunengda Tablets on mice
- VernacularTitle:血能达片对小鼠的急性毒性和抗栓疗效
- Author:
Haihong ZHENG
;
Xin GU
;
Chunshan GU
;
- Publication Type:Journal Article
- Keywords:
Xunengda Tablet collagen adr;
coagulation time;
writhing;
maximal tolerance
- From:
Chinese Traditional Patent Medicine
1992;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To determine the maximal tolerance of Xunengda Tablets on mice and explore curative effects of its antithrombotic effect and provide the theoretical basis for selecting drugs. Methods:Mice were given maximal dose, 26g?kg -1 of body weight, XND Ig once; Divided 53 mice into five groups, they were administered XND tab.(3g?kg -1 ), RSC(1.25g?kg -1 ), CDDP(1.25g?kg -1 ), XSTL(2.5g?kg -1 ), and NS once daily for 7 days, repectively; 1h after treatment the seventh day, the animals of groups iv. were given collagen adr by producing whole organism thrombus, observing the mortality, They were determined coagulation time with the blood capillaries and the number of writhings per mouse was recorded in order to determine pain. Results:Maximal tolerance (Ig) is 26g?kg -1 , 886.7 times the dose of clinical application apart from XSTL, three kinds of drug showed the avidence of antithrombotic effect ( P
