Study of protection of muscone against local cerebral ischemia
- VernacularTitle:麝香酮抗局灶性脑缺血损伤的实验研究
- Author:
Hui LIANG
;
Hu CHEN
;
Yin GAO
;
Dingfang CAI
;
- Publication Type:Journal Article
- Keywords:
local cerebral ischemia;
neuron protection;
neuronal glutamate tranporter;
muscone
- From:
Chinese Traditional Patent Medicine
1992;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of muscone on infarction volume and neuronal glutamate transporter EAAC1 mRNA expression in rats. Methods: Rats were divided randomly, focal ischemic models of middle cerebral artery occlusion (MCAO) were achieved by inserting nylon surgical thread through the internal carotid artery(ICA) into the anterior cerebral artery(ACA). The rats were sacrificed, the brain was stained by TTC and the area of infarcton was measured. The expression of EAACl mRNA in the hippocampal regions was assessed by RT PCR. Results: Muscone could remarkably reduce tbe infarction volume and expression of EAAC1 mRNA. Conclusion: Muscone plays a significant role in against local cerebral ischemia, the mechanism may be related to reducing EEACl mRNA expression.
